CLEC4E/MINCLE Monoclonal Antibody

Target Information

Target Name	CLEC4E/MINCLE
Uniprot ID	Q9ULY5
Cellular Localization	Membrane.
Immunogen	Recombinant fragment corresponding to Human CLEC4E/MINCLE aa 41-219.
Function	C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Product Details

Description	Mouse monoclonal antibody to CLEC4E/MINCLE.
Host Species	Mouse
Clonality	Monoclonal
Purity	Tissue culture supernatant
Isotype	IgG2b
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment corresponding to Human CLEC4E/MINCLE aa 41-219.
Positive Control	HeLa cells and HeLa whole cell lysate
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.1% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.