CLEC4E/MINCLE Polyclonal Antibody

Target Information

Target Name	CLEC4E/MINCLE
Uniprot ID	Q9ULY5
Cellular Localization	Membrane.
Immunogen	Recombinant fragment corresponding to Human CLEC4E/MINCLE aa 1 to the C-terminus.
Function	C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Product Details

Description	Rabbit polyclonal antibody to CLEC4E/MINCLE.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein G purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment corresponding to Human CLEC4E/MINCLE aa 1 to the C-terminus.
Positive Control	IHC-P: Human testis and kidney tissue. ICC/IF: U-251 MG cells.
Application	ICC/IF, IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Constituent: PBS, 50% Glycerol, 0.03% Proclin 300
Handling	Avoid freeze-thaw cycles.