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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

CMC2.24

Cat. No.: IBDI-431345

CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis.

Size (Solid):

Product Details

Target Ras | Apoptosis | MMP
Molecular Weight 427.45
Appearance Solid
Synonyms TRB-N0224
SMILES O=C(NC1=CC=CC=C1)C(C(/C=C/C2=CC=C(O)C=C2)=O)C(/C=C/C3=CC=C(O)C=C3)=O
Purity 96.48%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage -20°C
*In solvent : -80°C, 6 months; -20°C, 1 month
Handling Protect from light
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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