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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

CMLD012612

Cat. No.: IBDI-433027

CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity.

Size (Solid):

Product Details

Target Eukaryotic Initiation Factor (eIF)
Molecular Weight 559.61
Appearance Solid
SMILES CC1=N[[email protected]@]2(O)[[email protected]](C(N(OC)C)=O)[[email protected]@H](C3=CC=CC=C3)[[email protected]]4(C5=CC=C(OC)C=C5)OC6=C(C(OC)=CC(OC)=C6)[[email protected]@]42N1
Purity 99.52%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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