Coronin 1a/TACO Polyclonal Antibody

Target Information

Target Name	Coronin 1a/TACO
Uniprot ID	P31146
Cellular Localization	Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Cytoplasmic vesicle > phagosome membrane. In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
Immunogen	Synthetic peptide corresponding to Human Coronin 1a/TACO.
Function	May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Product Details

Description	Rabbit polyclonal antibody to Coronin 1a/TACO.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to Human Coronin 1a/TACO.
Positive Control	Jurkat whole cell lysate
Application	IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 6.8 Preservative: 0.09% Sodium Azide Constituent: 0.1% BSA, Tris Buffered Saline
Handling	Avoid freeze-thaw cycles.