Crizotinib-d5

Cat. No.: IBDI-434462

Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

Product Details

Target	Anaplastic lymphoma kinase (ALK) | c-Met/HGFR | ROS Kinase | Autophagy
Molecular Weight	455.37
Synonyms	PF-02341066-d5
SMILES	NC1=C(C=C(C=N1)C2=CN(N=C2)C3(C([2H])(CNCC3([2H])[2H])[2H])[2H])O[[email protected]](C)C4=C(C=CC(F)=C4Cl)Cl

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.