Crizotinib hydrochloride
Cat. No.: IBDI-433390
Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition.
Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution
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Product Details
| Target |
Anaplastic lymphoma kinase (ALK) | c-Met/HGFR | ROS Kinase | Autophagy |
| Molecular Weight |
486.80 |
| Appearance |
Solid |
| Synonyms |
PF-02341066 hydrochloride |
| SMILES |
ClC1=C(F)C=CC(Cl)=C1[[email protected]](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C.[H]Cl |
| Purity |
99.58% |
Storage & Handling
| Shipping |
Room temperature in continental US. May vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| Regulatory Status |
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. |
! For research use only, not intended for any clinical use.
