CUR61414

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Cat. No.: IBDI-432560

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Hedgehog \| Smo \| Apoptosis
Molecular Weight	550.69
Appearance	Solid
SMILES	CC(C)(C)CC(N([[email protected]@H]1CN(CC2=CC=C(OCO3)C3=C2)[[email protected]](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
Purity	99.04%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.