CXCR2-IN-2

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Inquiry

Cat. No.: IBDI-431492

CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM.

Size (Solid):

Product Details

Target	CXCR
Molecular Weight	414.90
Appearance	Solid
SMILES	O=C(N[[email protected]]1C(C)=CCC1)NC2=CC=C(Cl)C(S(=O)([[email protected]]3(C)COCC3)=O)=C2O
Purity	99.35%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.