CXCR4 Monoclonal Antibody

Target Information

Target Name	CXCR4
Uniprot ID	P61073
Cellular Localization	Cell membrane. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.
Immunogen	Synthetic peptide.
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Product Details

Description	Rabbit monoclonal antibody to CXCR4.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Human, Recombinant fragment
Immunogen	Synthetic peptide.
Positive Control	WB: Jurkat whole cell lysate. IF/ICC: Jurkat and Ramos cells. IHC-P: Retina and brain of E14 mouse embryo, Human small cell lung carcinoma tissue. Flow Cyt (Intra): Jurkat cells.
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.5% BSA
Handling	Avoid freeze-thaw cycles.