Cat. No.: IBDA-432395
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Online InquiryTarget Information
| Target Name | CXCR4 |
| Uniprot ID | P61073 |
| Cellular Localization | Cell membrane. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. |
| Immunogen | Synthetic peptide within Human CXCR4 aa 300 to the C-terminus (C terminal). |
| Function | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. |
Product Details
| Description | Rabbit monoclonal antibody to CXCR4. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Rat, Human |
| Immunogen | Synthetic peptide within Human CXCR4 aa 300 to the C-terminus (C terminal). |
| Positive Control | WB: HeLa, Jurkat and WI-38 cell lysates. HEK239 transfected with CXCR4, cell lysate. ICC/IF: Jurkat cells. IHC-P: Human cervical carcinoma, bladder cancer tissue, ovarian adenocarcinoma tissue and tonsil tissue. Flow Cyt (Intra): Jurkat cells, HEK-293T cells transfected with human CXCR4 expressed vector. IHC-Fr: Mouse and rat E14.5 cerebrum |
| Application | Flo, ICC/IF, IHC-Fr, IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 40% Glycerol, 0.05% BSA, 59% PBS |
| Handling | Avoid freeze-thaw cycles. |