CXCR4 Monoclonal Antibody

Target Information

Target Name	CXCR4
Uniprot ID	P61073
Cellular Localization	Cell membrane. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.
Immunogen	Tissue, cells or virus.
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Product Details

Description	APC Mouse monoclonal antibody to CXCR4.
Host Species	Mouse
Clonality	Monoclonal
Purity	Size exclusion
Isotype	IgG2a
Conjugation	APC
Reactivity	Human, Non human primates
Immunogen	Tissue, cells or virus.
Positive Control	Flow: Peripheral whole blood cells, lymphocytes.
Application	Flo

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at 4 °C. Store in the dark
Storage Buffer	pH: 7.4 Preservative: 0.1% Sodium Azide Constituent: PBS