CYR61/CCN1 Polyclonal Antibody

Target Information

Target Name	CYR61/CCN1
Uniprot ID	O00622
Cellular Localization	Secreted.
Immunogen	Recombinant fragment within Human CYR61/CCN1 (internal sequence).
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Product Details

Description	Rabbit polyclonal antibody to CYR61/CCN1.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Rat, Human
Immunogen	Recombinant fragment within Human CYR61/CCN1 (internal sequence).
Positive Control	WB: Brefeldin A-treated HeLa whole cell extract. IHC-P: Rat intestine tissue. ICC/IF: HeLa cells.
Application	ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7 Preservative: 0.01% Thimerosal (Merthiolate) Constituent: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Handling	Avoid freeze-thaw cycles.