D-α-Hydroxyglutaric acid disodium

Cat. No.: IBDI-431523

D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

Product Details

Target	Reactive Oxygen Species | ATP Synthase | mTOR | Endogenous Metabolite
Molecular Weight	192.08
Appearance	Solid
Synonyms	Disodium (R)-2-hydroxyglutarate
SMILES	O=C(O[Na])[[email protected]](O)CCC(O[Na])=O
Purity	≥98.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	4°C *In solvent : -80°C, 6 months; -20°C, 1 month
Handling	Sealed storage, away from moisture
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.