D-α-Hydroxyglutaric acid

Cat. No.: IBDI-431518

D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

Product Details

Target	Reactive Oxygen Species | ATP Synthase | mTOR | Endogenous Metabolite
Molecular Weight	148.11
Synonyms	(R)-2-Hydroxyglutarate, (R)-2-Hydroxyglutaric acid, (R)-2-Hydroxypentanedioic acid
SMILES	O=C(O)[[email protected]](O)CCC(O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.