DAPT

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Cat. No.: IBDI-434096

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	γ-secretase \| Amyloid-β \| Autophagy \| Notch \| Apoptosis
Molecular Weight	432.46
Appearance	Solid
Synonyms	GSI-IX
SMILES	FC1=CC(F)=CC(CC(N[[email protected]](C(N[[email protected]](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
Purity	99.93%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.