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DI-591

Cat. No.: IBDI-435936

DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members.

Size (Solid):

Product Details

Target E1/E2/E3 Enzyme
Molecular Weight 585.80
Appearance Solid
SMILES O=C(N[[email protected]@H](C1CCCCC1)CNC(CCN2CCOCC2)=O)[[email protected]@H](NC(CC)=O)CC3=NC4=CC=C(C(C)C)C=C4S3
Purity 99.42%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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