Products
  1. Home
  2. Products
  3. Inhibitors & Activators for IBD Research
Products
Inquiry

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Divarasib

Cat. No.: IBDI-434509

Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.

Size (Solid):

Product Details

Target Ras
Molecular Weight 622.06
Appearance Solid
Synonyms GDC-6036
SMILES NC1=N[[email protected]]([[email protected]]2=C(C=C3C(N=C(N=C3N4[[email protected]](CN(CC4)C(C=C)=O)C)OC[[email protected]]5N(CCC5)C)=C2F)Cl)=C(C(C)=C1)C(F)(F)F
Purity 99.46%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years; 4°C/2 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
Copyright © Ace Therapeutics. All rights reserved.