DM1-SMe

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Inquiry

Cat. No.: IBDI-432373

DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent agent Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.

Size (Solid):

Product Details

Target	Microtubule/Tubulin \| ADC Cytotoxin
Molecular Weight	784.38
Appearance	Solid
SMILES	C[[email protected]]12[[email protected]@]([[email protected]@H]([[email protected]]3([H])C[[email protected]]([[email protected]@H](/C=C/C=C(CC4=CC(N(C(C[[email protected]@H]2OC([[email protected]](C)N(C)C(CCSSC)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Purity	98.02%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.