Dolutegravir sodium
Cat. No.: IBDI-435554
Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution
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Product Details
| Target |
HIV | IntegRase | HIV |
| Molecular Weight |
441.36 |
| Appearance |
Solid |
| Synonyms |
S/GSK1349572 sodium |
| SMILES |
O=C(C1=CN(C2=C(O[Na])C1=O)C[[email protected]]3([H])OCC[[email protected]@H](C)N3C2=O)NCC4=CC=C(F)C=C4F |
| Purity |
99.88% |
Storage & Handling
| Shipping |
Room temperature in continental US. May vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| Regulatory Status |
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. |
! For research use only, not intended for any clinical use.
