EMA/MUC1 Monoclonal Antibody

Target Information

Target Name	EMA/MUC1
Synonyms	MUC1 | CA15-3 | CD227 | Carcinoma-associated mucin | CD227 antigen | DF3 antigen | Episialin | Epithelial membrane antigen | H23 antigen | H23AG | Krebs von den Lungen-6 | MAM6 | MUC1/ZD | MUC-1/SEC | Mucin-1 | Pem | KL-6 | MUC-1/X | Tumor-associated mucin | Peanut-reactive urinary mucin | Polymorphic epithelial mucin | PUM | EMA | MUC-1 | Mucin 1, transmembrane
Uniprot ID	P15941
Immunogen	Live cells (107 cells/dose in PBS) of human breast cancer cell line ZR-75-1. Splenocytes were fused with SP2/0 mouse myeloma cells. Stability of the hybridomas was established by subcloning four times.

Product Details

Description	MUC1 antibody is an unconjugated mouse monoclonal antibody to human MUC1 (EMA).
Host Species	Mouse
Clonality	Monoclonal
Purity	Purified
Conjugation	Unconjugated
Modifications	Concentrated
Reactivity	Human
Specificity	VU-11E2 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of mAb VU11E2 is the 7-mer TSAPDTR of the MUC1 tandem repeat as established with epitope fingerprinting.
Immunogen	Live cells (107 cells/dose in PBS) of human breast cancer cell line ZR-75-1. Splenocytes were fused with SP2/0 mouse myeloma cells. Stability of the hybridomas was established by subcloning four times.
Application	ELISA, Flo, IHC, IHC-Fr, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at 4 °C
Storage Buffer	PBS, 0.05% Sodium Azide