EMA/MUC1 Monoclonal Antibody

Target Information

Target Name	EMA/MUC1
Synonyms	MUC1 | CA15-3 | CD227 | Carcinoma-associated mucin | CD227 antigen | DF3 antigen | Episialin | Epithelial membrane antigen | H23 antigen | H23AG | Krebs von den Lungen-6 | MAM6 | MUC1/ZD | MUC-1/SEC | Mucin-1 | Pem | KL-6 | MUC-1/X | Tumor-associated mucin | Peanut-reactive urinary mucin | Polymorphic epithelial mucin | PUM | EMA | MUC-1 | Mucin 1, transmembrane
Uniprot ID	P15941
Immunogen	Recombinant full-length human MUC1 protein. Antigen Molecular Weight: 265-400 kDa.

Product Details

Description	Rabbit monoclonal antibody to EMA/MUC1.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A/G purified
Conjugation	Unconjugated
Modifications	Unmodified. Also available Azide-free, Carrier-free.
Reactivity	Human
Specificity	This MAb reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. It is used as tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up-regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of this MAb involves both amino acids as well as sugar moieties. Its epitope is destroyed by desialylation i.e. treatment with Neuraminidase.
Immunogen	Recombinant full-length human MUC1 protein. Antigen Molecular Weight: 265-400 kDa.
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at 4 °C
Storage Buffer	10 mM PBS, 0.05% BSA, 0.05% Sodium Azide