EMAP II/AIMP1 Polyclonal Antibody

Target Information

Target Name	EMAP II/AIMP1
Uniprot ID	Q12904
Cellular Localization	Nucleus. Cytoplasm > cytosol. Cytoplasmic vesicle > secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
Immunogen	Recombinant fragment corresponding to Human EMAP II/AIMP1 aa 1-233 (N terminal).
Function	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Product Details

Description	Rabbit polyclonal antibody to EMAP II/AIMP1.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment corresponding to Human EMAP II/AIMP1 aa 1-233 (N terminal).
Application	ICC/IF, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7 Preservative: 0.01% Thimerosal (Merthiolate) Constituent: 1.21% Tris, 0.75% Glycine, 10% Glycerol
Handling	Avoid freeze-thaw cycles.