Enpatoran hydrochloride
Cat. No.: IBDI-431930
Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research.
Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution
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Product Details
| Target |
Toll-like Receptor (TLR) |
| Molecular Weight |
356.77 |
| Appearance |
Solid |
| Synonyms |
M5049 hydrochloride |
| SMILES |
[H]Cl.N#CC(C=C1)=C(N=CC=C2)C2=C1N3C[[email protected]@H](C(F)(F)F)C[[email protected]@H](N)C3 |
| Purity |
98.82% |
Storage & Handling
| Shipping |
Room temperature in continental US. May vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| Regulatory Status |
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. |
! For research use only, not intended for any clinical use.
