Eurycomalactone

Cat. No.: IBDI-431063

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF‑κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394).

Product Details

Target	NF-κB | Apoptosis | Akt | Bcl-2 Family
Molecular Weight	348.39
Appearance	Solid
SMILES	C[[email protected]]12[[email protected]@]([[email protected]]([[email protected]@](O3)([H])[[email protected]@](C)([H])[[email protected]]2([H])C3=O)O)([H])[[email protected]]([[email protected]@](C(C)=CC4=O)([H])CC1=O)([[email protected]@H]4O)C
Structure Classification	Terpenoids>Diterpenoids
Purity	93.24%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.