Cat. No.: IBDA-433258
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Online InquiryTarget Information
| Target Name | Fas |
| Uniprot ID | P25445 |
| Cellular Localization | Secreted and Cell membrane. |
| Immunogen | Recombinant fragment. |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
Product Details
| Description | Rabbit monoclonal antibody to Fas - BSA and Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse |
| Immunogen | Recombinant fragment. |
| Positive Control | WB: Mouse spleen, skin, liver, heart, lung, thymus and stomach tissue lysates. A20 and J774A.1 whole cell lysates. IHC-P: Mouse thymus, spleen and lung cancer tissue. IHC-Fr: Mouse thymus and liver (fresh) tissue. IP: Mouse thymus tissue lysate. |
| Application | IHC-Fr, IHC-P, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.2 Constituent: 100% PBS |