Fas Monoclonal Antibody

Target Information

Target Name	Fas
Uniprot ID	P25445
Cellular Localization	Secreted and Cell membrane.
Immunogen	Recombinant fragment.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Product Details

Description	Rabbit monoclonal antibody to Fas.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse
Immunogen	Recombinant fragment.
Positive Control	WB: Mouse spleen, skin, liver, heart, lung, thymus and stomach tissue lysates. A20 and J774A.1 whole cell lysates. IHC-P: Mouse thymus, spleen and lung cancer tissue. IHC-Fr: Mouse thymus and liver (fresh) tissue. IP: Mouse thymus tissue lysate.
Application	IHC-Fr, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA
Handling	Avoid freeze-thaw cycles.