Fas Monoclonal Antibody

Target Information

Target Name	Fas
Uniprot ID	P25445
Cellular Localization	Secreted and Cell membrane.
Immunogen	The details of the immunogen for this antibody are not available.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Product Details

Description	Mouse monoclonal antibody to Fas - Low Endotoxin, Azide Free.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgM
Conjugation	Unconjugated
Reactivity	Human
Immunogen	The details of the immunogen for this antibody are not available.
Positive Control	Human peripheral blood leukocytes. stimulated Jurkat cells.
Application	Flo

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2aqueous buffer, no Sodium Azide
Handling	Avoid freeze-thaw cycles.