Fas Polyclonal Antibody

Target Information

Target Name	Fas
Uniprot ID	P25445
Cellular Localization	Secreted and Cell membrane.
Immunogen	Synthetic peptide within Human Fas aa 285-335.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Product Details

Description	Rabbit polyclonal antibody to Fas.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human Fas aa 285-335.
Positive Control	WB: HeLa and KEK-293T whole cell lysates. IP: HeLa whole cell lysate.
Application	IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7 Preservative: 0.09% Sodium Azide Constituent: Tris Citrate/Phosphate
Handling	Avoid freeze-thaw cycles.