Fas Polyclonal Antibody

Target Information

Target Name	Fas
Uniprot ID	P25445
Cellular Localization	Secreted and Cell membrane.
Immunogen	Synthetic peptide corresponding to Human Fas aa 150-250 (internal sequence).
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Product Details

Description	Goat polyclonal antibody to Fas.
Host Species	Goat
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to Human Fas aa 150-250 (internal sequence).
Positive Control	Human small intestine tissue, Human tonsil tissue, MOLT4 cell lysate.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.30 Preservative: 0.02% Sodium Azide Constituent: Tris Buffered Saline, 0.5% BSA
Handling	Avoid freeze-thaw cycles.