Fas Polyclonal Antibody

Target Information

Target Name	Fas
Uniprot ID	P25445
Cellular Localization	Secreted and Cell membrane.
Immunogen	Synthetic peptide corresponding to Mouse Fas conjugated to keyhole limpet haemocyanin.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Product Details

Description	Rabbit polyclonal antibody to Fas.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat
Immunogen	Synthetic peptide corresponding to Mouse Fas conjugated to keyhole limpet haemocyanin.
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.09% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.