Fludarabine triphosphate trisodium

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Fludarabine triphosphate trisodium

Cat. No.: IBDI-434639

Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.

Size (Solution): 10 mM * 1 mL in Water

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Nucleoside Antimetabolite/Analog \| Drug Metabolite \| DNA/RNA Synthesis \| Apoptosis
Molecular Weight	591.12
Appearance	Solid
Synonyms	F-ara-ATP trisodium
SMILES	O[[email protected]@H]([[email protected]@H]1O)[[email protected]](O[[email protected]@H]1CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(F)=NC(N)=C3N=C2
Purity	≥95.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.