FXR antagonist 1

Cat. No.: IBDI-437927

FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies.

Product Details

Target	FXR |
Molecular Weight	585.86
SMILES	OC(CNC([[email protected]]12[[email protected]@]([[email protected]@H](CC2)C(C)C)([H])[[email protected]]3([H])[[email protected]@](CC1)([[email protected]]4([[email protected]]([[email protected]@]5([[email protected]@](C(C)([[email protected]@H](CC5)OC(CCC)=O)C)([H])CC4)C)([H])CC3)C)C)=O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.