G12Si-5 formic

Cat. No.: IBDI-433465

G12Si-5 formic is a covalent inhibitor of the G12S mutant of K-Ras (Ki: 26 μM). G12Si-5 formic binds with the S-IIP domain and suppresses oncogenic signaling. G12Si-5 formic reduces phospho-ERK level in KRAS G12S mutated cells.

Product Details

Target	Ras
Molecular Weight	620.07
SMILES	ClC1=CC=CC2=CC=CC(C3=C(F)C4=C(C(N5CC[[email protected]]6C(O[[email protected]]6C5)=O)=NC(OCC78CCCN7CCC8)=N4)C=N3)=C12.OC=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.