Products
  1. Home
  2. Products
  3. Inhibitors & Activators for IBD Research
Products
Inquiry

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

G12Si-5

Cat. No.: IBDI-433464

G12Si-5 is a covalent inhibitor of the G12S mutant of K-Ras (Ki: 26 μM). G12Si-5 binds with the S-IIP domain and suppresses oncogenic signaling. G12Si-5 reduces phospho-ERK level in KRAS G12S mutated cells.

Size (Solid):

Product Details

Target Ras
Molecular Weight 574.05
SMILES ClC1=CC=CC2=CC=CC(C3=C(F)C4=C(C(N5CC[[email protected]]6C(O[[email protected]]6C5)=O)=NC(OCC78CCCN7CCC8)=N4)C=N3)=C12

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
Copyright © Ace Therapeutics. All rights reserved.