Gliotoxin

Cat. No.: IBDI-430207

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells.

Product Details

Target	Apoptosis | PKA | NF-κB | Bacterial | Fungal | Antibiotic
Molecular Weight	326.39
Appearance	Solid
Synonyms	Aspergillin
SMILES	O=C1N(C)[[email protected]@]2(CO)C(N3[[email protected]@]1(SS2)CC4=CC=C[[email protected]](O)[[email protected]@]34[H])=O
Structure Classification	Antibiotics
Purity	98.78%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.