β-Glucuronide-dPBD-PEG5-NH2

Cat. No.: IBDI-434622

β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity.

Product Details

Target	Drug-Linker Conjugates for ADC | Apoptosis
Molecular Weight	1696.66
SMILES	NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[[email protected]](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[[email protected]@H]8O[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[[email protected]](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[[email protected]@H]%10O[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]%10O)O)O)C(O)=O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.