HMW Kininogen Polyclonal Antibody

Target Information

Target Name	HMW Kininogen
Uniprot ID	P01042
Cellular Localization	Secreted > extracellular space.
Immunogen	HMW Kininogen purified from human plasma.
Function	(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Product Details

Description	Rabbit polyclonal antibody to HMW Kininogen.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein G purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	HMW Kininogen purified from human plasma.
Application	ICC/IF

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.50 Preservative: 0.01% Thimerosal (Merthiolate) Constituent: PBS, 50% Glycerol
Handling	Avoid freeze-thaw cycles.