Cat. No.: IBDAK-621019
Size:
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| Sample Type | Cell culture supernatant, Urine, Serum, Tissue Extracts, Hep Plasma, EDTA Plasma, Cit plasma |
| Detection Method | Colorimetric |
| Assay Type | Sandwich (quantitative) |
| Assay Time | 1 h 30 min |
| Assay Duration | One step assay |
| Product Type | Cell Type Markers |
| Sensitivity | 4.9 pg/ml |
| Range | 23.44 pg/ml - 1500 pg/ml |
| Species Reactivity | Reacts with: Human Does not react with: Cow |
| Platform | Pre-coated microplate (12 x 8 well strips) |
Target
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |
| Sequence Similarities | Contains 1 UPAR/Ly6 domain. |
| Cellular Localization | Cell membrane. Secreted. Soluble form found in a number of tissues. |
Storage & Handling
| Storage | Store at -20°C. Please refer to protocols. |