Human MyD88 ELISA Kit

Overview

Sample Type	Cell culture supernatant, Cell Lysate, Hep Plasma, EDTA Plasma
Detection Method	Colorimetric
Assay Type	Sandwich (quantitative)
Assay Duration	Multiple steps standard assay
Product Type	TLR Signaling
Sensitivity	< 10 pg/ml
Range	156 pg/ml - 10000 pg/ml
Species Reactivity	Reacts with: Human
Platform	Microplate

Target

Function	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
Tissue Specificity	Ubiquitous.
Sequence Similarities	Contains 1 death domain. Contains 1 TIR domain.
Cellular Localization	Cytoplasm.
Domain	The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS