Human TAB2 Antibody Pair - BSA and Azide free

Overview

Assay Type	ELISA set
Product Type	TLR Signaling
Range	125 pg/ml - 8000 pg/ml
Species Reactivity	Reacts with: Human
Platform	Reagents
Application	Sandwich ELISA

Properties

Carrier Free

Yes

Target

Function	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
Tissue Specificity	Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Sequence Similarities	Contains 1 CUE domain. Contains 1 RanBP2-type zinc finger.
Cellular Localization	Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS