Human TIMP1 ELISA Kit

Overview

Sample Type	Cell culture extracts, Tissue Extracts
Detection Method	Colorimetric
Assay Type	Sandwich (quantitative)
Assay Duration	Multiple steps standard assay
Product Type	Chemokines
Sensitivity	< 30 pg/ml
Range	24.69 pg/ml - 18000 pg/ml
Species Reactivity	Reacts with: Human
Platform	Microplate

Target

Function	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
Sequence Similarities	Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain.
Cellular Localization	Secreted.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS