Human uPA Receptor/U-PAR ELISA Kit (URKR)

Overview

Sample Type	Cell culture supernatant, Serum, Plasma, Other biological fluids, Tissue Extracts
Detection Method	Colorimetric
Assay Type	Sandwich (quantitative)
Assay Duration	Multiple steps standard assay
Product Type	Cell Type Markers
Sensitivity	< 4 pg/ml
Range	62.5 pg/ml - 4000 pg/ml
Species Reactivity	Reacts with: Human
Platform	Microplate

Target

Function	Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Tissue Specificity	Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Sequence Similarities	Contains 3 UPAR/Ly6 domains.
Cellular Localization	Secreted and Cell membrane.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS