Cat. No.: IBDA-432435
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Online InquiryTarget Information
| Target Name | Iba1 |
| Uniprot ID | P55008 |
| Cellular Localization | Cytoplasm > cytoskeleton. Cell projection > ruffle membrane. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. |
| Immunogen | Synthetic peptide. |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
Product Details
| Description | Rat monoclonal antibody to Iba1 - Rat IgG2a. |
| Host Species | Rat |
| Clonality | Monoclonal |
| Purity | Ion Exchange Chromatography |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Rat, Human |
| Immunogen | Synthetic peptide. |
| Positive Control | WB: THP-1 whole cell lysate. IHC-P: Human cerebrum and endometrium tissue. Mouse and rat cerebrum tissue. ICC/IF: THP-1 cells. Flow Cyt: THP-1 cells. IP: THP-1 cell lysate. |
| Application | Flo, ICC/IF, IHC-P, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 0.05% BSA, 40% Glycerol |
| Handling | Avoid freeze-thaw cycles. |