Cat. No.: IBDA-433214
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Online InquiryTarget Information
| Target Name | IKB Alpha |
| Uniprot ID | P25963 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Immunogen | Synthetic peptide within Human IKB alpha aa 300 to the C-terminus. |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Product Details
| Description | Rabbit monoclonal antibody to IKB alpha. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Alexa Fluor® 647 |
| Reactivity | Human |
| Immunogen | Synthetic peptide within Human IKB alpha aa 300 to the C-terminus. |
| Positive Control | ICC/IF: HeLa cells |
| Application | ICC/IF |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C. Store in the dark |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: 30% Glycerol, 1% BSA, PBS |
| Handling | Avoid freeze-thaw cycles. |