Cat. No.: IBDA-433229
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Online InquiryTarget Information
| Target Name | IKB Alpha (phospho S32) |
| Uniprot ID | P25963 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Immunogen | Synthetic peptide within Human IKB alpha aa 1-100 (phospho S32). |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Product Details
| Description | Rabbit monoclonal antibody to IKB alpha (phospho S32). |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide within Human IKB alpha aa 1-100 (phospho S32). |
| Positive Control | WB: TNF-a treated HeLa and TNF-a treated MCF7 whole cell lysates. IP: TNF-a treated HeLa whole cell lysate. |
| Application | Dot, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |