Cat. No.: IBDA-433227
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Online InquiryTarget Information
| Target Name | IKB Alpha (phospho S36) |
| Uniprot ID | P25963 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Immunogen | Synthetic peptide. |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Product Details
| Description | Rabbit monoclonal antibody to IKB alpha (phospho S36). |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Rat, Human |
| Immunogen | Synthetic peptide. |
| Positive Control | HeLa cells treated with FBS and Calyculin A. |
| Application | Flo, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 59% PBS, 40% Glycerol, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |