Cat. No.: IBDA-433218
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Online InquiryTarget Information
| Target Name | IKB Alpha (phospho Y42) |
| Uniprot ID | P25963 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Immunogen | Synthetic peptide. |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Product Details
| Description | Rabbit monoclonal antibody to IKB alpha (phospho Y42) - BSA and Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.2 Constituent: PBS |
| Handling | Do not freeze. |