IKB Alpha Polyclonal Antibody

Target Information

Target Name	IKB Alpha
Uniprot ID	P25963
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Immunogen	Recombinant full length protein (Mouse).
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Product Details

Description	Rabbit polyclonal antibody to IKB alpha.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse
Immunogen	Recombinant full length protein (Mouse).
Positive Control	WB: mouse brain tissue lysate
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.1% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.