IKB Alpha Polyclonal Antibody

Target Information

Target Name	IKB Alpha
Uniprot ID	P25963
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Immunogen	Synthetic peptide corresponding to Human IKB alpha aa 1-100 conjugated to keyhole limpet haemocyanin.
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Product Details

Description	Rabbit polyclonal antibody to IKB alpha.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human, Recombinant fragment
Immunogen	Synthetic peptide corresponding to Human IKB alpha aa 1-100 conjugated to keyhole limpet haemocyanin.
Positive Control	Recombinant Human IKB alpha protein can be used as a positive control in WB. This antibody gave a positive signal in HAP1 (WT) and HeLa whole cell lysates, Human kidney and Human spleen tissue lysates. ICC/IF: HeLa cells.
Application	ICC/IF, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.